ABSTRACT
OBJECTIVE:To observe the efficacy and safety of low-dose Progesterone injection combined with Baotai wuyou capsule in the treatment of threatened abortion. METHODS:107 patients with threatened abortion were retrospectively analyzed and divided into observation group(54 cases)and control group(53 cases)by different medication. All patients received bed rest orally taking folic acid and other measures. Meanwhile,control group was given Progesterone injection 20-40 mg,qd,intramuscu-larly injected. Observation group was given Progesterone injection 10-20 mg,qd,intramuscularly injected and given 4 Baotai wuy-ou capsule additionally,tid,taking with ginger decoction,no fish during the medication. The courses of 2 groups were 14 d. Clini-cal efficacy,hemostatic time,remission time of abdominal pain and backache in 2 groups were observed,and the incidence of ad-verse reactions during the treatment was recorded. RESULTS:The total effective rate in observation group was significantly higher than control group,hemostatic time,remission time of abdominal pain and backache were significantly shorter than control group, the incidence of adverse reactions was significantly lower than control group,with statistical significances (P<0.05). CONCLU-SIONS:Low-dose Progesterone injection combined with Baotai wuyou capsule shows good efficacy in the treatment of threatened abortion,which can shorten patients'hemostatic time,remission time of abdominal pain and backache,and reduce the incidence of adverse reactions,with good safety.
ABSTRACT
OBJECTIVE:To discuss clinical efficacy and safety of leuprolide acetate in the treatment of endometriosis. METH-ODS:66 endometriosis patients were divided into observation group(37 cases)and control group(29 cases)according to random number table method. Observation group was treated with Leuprolide acetate microsphere for injection,3.75 mg/time,on the upper arm,abdomen or buttocks since the first-fifth day of menstrual cycle(administration time was available at hysterectomized patients disposal),and then every 4 weeks;one administration was recognized as a treatment course. Control group was treated with Ethi-nyl estradiol cyproterone tablet orally,1 tablets per day for 3 weeks,one week drug withdrawal,as a treatment course. 2 groups were given 3-5 courses of treatment according to their tolerance or the improvement of clinical symptoms. The improvement of clini-cal symptoms were compared between 2 groups,and the levels of FSH,LH and E2 were compared before and after treatment;the occurrence of ADR and the time of the return of menses were recorded. RESULTS:2 patients in observation group and 1 patient in control group withdrew from the test. After treatment,total effective rate was 97.14% in observation group,which was significant-ly higher than 75.00% in control group,with statistical significance (P0.05). After treatment,the levels of FSH,LH and E2 were de-creased significantly,and the observation group was more significant than the control group,with statistical significance (P0.05). The time of the return of menses in observation group was (89.75 ± 3.34) d after drug withdrawal,com-pared to control group [(88.46±2.94)d],there was no statistical significance(P>0.05). CONCLUSIONS:Leuprolide acetate can effectively improve clinical symptoms of patients with endometriosis,and reduce the levels of FSH,LH and E2 with slight ADR, and it doesn’t influence the time of the return of menses.